Reply to: [Factor XI mutation and the origin of Ashkenazi Jews. Haematologica 2008; 93:e59]
نویسندگان
چکیده
منابع مشابه
Factor XI mutation and the origin of Ashkenazi Jews.
1. Zadra G, Asselta R, Tenchini ML, Castaman G, Seligsohn U, Mannucci PM, et al. Simultaneous genotyping of coagulation factor XI type II and type III mutations by multiplex real-time polymerase chain reaction to determine their prevalence in healthy and factor XI-deficient Italians. Haematologica 2008; 93:715-21. 2. Rodriguez-Mari A, Diaz-Font A, Chabas A, Pastores GM, Grinberg D, Vilageliu L....
متن کاملTwo common mutations causing factor XI deficiency in Ashkenazi Jews may point to a European origin.
Shpilberg et al’ suggest that the occurrence of type I1 mutation in the factor XI gene in both Ashkenazi and Iraqi Jews attests to its presence in Jews already 2,500 years ago. They ignore the fact that both type I1 and type III mutations, which are common in Ashkenazi Jews, are also common in northwest England.2 A Pst+ polymorphism in the HEXA gene was also found in both Ashkenazi and Scots-Ir...
متن کاملHigh gene frequency of factor XI (PTA) deficiency in Ashkenazi Jews.
Factor Xi deficiency has previously been observed mainly in Jews. For 34 of 36 probands with factor XI deficiency in Israel, reliable information on ethnic background was obtained. Of 34 probands 33 were of definite Ashkenazi Jewish origin; 1 was of probable Ashkenazi origin. From a survey of factor Xi levels among 428 unrelated healthy Ashkenazi Jews, 35 had partial factor XI deficiency (facto...
متن کاملNo evidence from genome-wide data of a Khazar origin for the Ashkenazi Jews.
The origin and history of the Ashkenazi Jewish population have long been of great interest, and advances in high-throughput genetic analysis have recently provided a new approach for investigating these topics. We and others have argued on the basis of genome-wide data that the Ashkenazi Jewish population derives its ancestry from a combination of sources tracing to both Europe and the Middle E...
متن کاملHLA class II susceptibility to multiple sclerosis among Ashkenazi and non-Ashkenazi Jews.
OBJECTIVE To look for HLA class II alleles and haplotypes conferring susceptibility to multiple sclerosis (MS) in the Jewish population of Israel. DESIGN Population-based cohort of clinically definite patients with MS tested prospectively over 7 years. SETTING Referral center in a neurology clinic at a university hospital in the greater Jerusalem area in Israel. PATIENTS A total of 162 co...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2008
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.13480